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beta Catenin antibody (N-Term)

The Mouse Monoclonal anti-beta Catenin antibody has been validated for WB, FACS and IF. It is suitable to detect beta Catenin in samples from Human, Mouse and Rat.
Catalog No. ABIN4949461

Quick Overview for beta Catenin antibody (N-Term) (ABIN4949461)

Target

See all beta Catenin (CATNB) Antibodies
beta Catenin (CATNB) (Catenin, beta (CATNB))

Reactivity

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Human, Mouse, Rat

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This beta Catenin antibody is un-conjugated

Application

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Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone

12F7
  • Binding Specificity

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    N-Term

    Purification

    Protein G affinity chromatography

    Immunogen

    A recombinant fusion protein consisting of the N-terminal half of human beta-Catenin fused to maltose binding protein was used as the immunogen for the Beta Catenin antibody.

    Isotype

    IgG1 kappa
  • Application Notes

    Titration of the Beta Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL,WB: 1-2 μg/mL

    Restrictions

    For Research Use only
  • Concentration

    1 mg/mL

    Buffer

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    Preservative

    Azide free

    Storage

    4 °C,-20 °C

    Storage Comment

    Store the Beta Catenin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target

    beta Catenin (CATNB) (Catenin, beta (CATNB))

    Alternative Name

    Beta Catenin

    Background

    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. [RefSeq]

    Pathways

    Peptide Hormone Metabolism
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